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Codeine combined with an antihistamine, and sometimes caffeine, is marketed below different trade names and is on the market and not using a prescription. These products and solutions are retained driving the counter and have to be dispensed by a pharmacist who could limit portions.[citation needed]
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Experiments on codeine's analgesic influence are in keeping with the concept that metabolism by CYP2D6 to morphine is essential, but some scientific studies display no important differences between those people who are inadequate metabolizers and considerable metabolizers.
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Tips produced by the Clinical Pharmacogenomics Implementation Consortium (CPIC) advise versus administering codeine to ultrarapid metabolizers, exactly where this genetic data is out there. The CPIC also suggests that codeine use be prevented in weak metabolizers, as a result of its deficiency of efficacy in this group.[43]
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As a consequence of improved metabolism of codeine to morphine, ultrarapid metabolizers (These possessing much more than two useful copies from the CYP2D6 allele) are at greater threat of adverse drug consequences connected with morphine toxicity.
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